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Although the bodybuilders who discontinued steroid use experienced improvement in their kidney abnormalities, one individual with advanced kidney disease progressed to ESRD and required dialysis. The authors speculated that this might be because of the presence of the AIT2 gene, which is more abundant in renal disease subjects. Treatment of those subjects who remained AIT2 positive for many years and had failed steroid treatment or required dialysis was not available. In those subjects, the authors believe that the authors' analysis suggests that continued use of the AIT2 steroid was associated with increased risk of ESRD, and a possible therapeutic target could be development of a drug to block this mechanism. The authors conclude that, at least in the short term, continuing use of AIT2 steroid was associated with risk of developing kidney disease, and treatment might be warranted for such individuals. Therefore, for those concerned about their kidney health, there is certainly a need for more studies to shed further light on the potential benefits and risks of continued usage of AIT2. Similar articles:
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